HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → Ethyl 2,7-diazabicyclo[3.3.0]octane-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 5-(1,1-Dimethylethyl) 1-ethyl hexahydropyrrolo[3,4-b]pyrrole-1,5-dicarboxylate | HCID 19100933 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Ethyl 2,7-diazabicyclo[3.3.0]octane-2-carboxylate | HCID 15070028 | — |
Reaction Steps
15.2 g (53.5 mmol) of 2-ethyl 7-tert.-butyl 2,7-diazabicyclo[3.3.0]octane-2,7-dicarboxylate in 100 ml of chloroform are heated under reflux for five hours with 10.5 g (55.3 mol) of para-toluenesulphonic acid. The mixture is washed with 50 ml of 10% strength sodium hydroxide solution, the organic phase is dried over potassium carbonate and concentrated, and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05177210 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-2ae87d81007344ceb226f24f4df437d5 |
| Source note | uspto-grants-1993_01 |