2-(Benzylamino)acetic acid → HCID 19100935, compound

HRID 1646031Notes

Reaction equation

HRID 1646031 reaction equation
[F:1][C:2](=[CH2:13])[CH2:3][N:4]([CH2:10][CH:11]=O)[C:5](=[O:9])[O:6][CH2:7][CH3:8].[CH2:14]([NH:21][CH2:22]C(O)=O)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[CH2:14]([N:21]1[CH2:22][CH2:13][C:2]2([F:1])[CH:11]1[CH2:10][N:4]([C:5]([O:6][CH2:7][CH3:8])=[O:9])[CH2:3]2)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 869652-(Benzylamino)acetic acidHCID 19738527HCID 19738527, compound

Product 1

HCID 19100935HCID 19100935, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

20.8 g (0.11 mol) of ethyl N-(2-fluoroallyl)-N-(2-oxoethyl)-carbamate are heated under reflux with 19 g (0.115 mol) of N-benzylglycine in 300 ml of toluene until evolution of CO is complete. The mixture is concentrated and the residue is distilled.

Workup

  1. concentrationThe mixture is concentrated
  2. distillationthe residue is distilled

Sources & evidence

ORD record
ord-e6fa1271bbae4a3f8cc20a7944ae63f5
Source dataset
uspto-grants-1993_01
Patent number
US05177210

Reaction notes

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