HCID 19100960, compound → HCID 19100975, compound

HRID 1646033Notes

Reaction equation

HRID 1646033 reaction equation
C([N:8]1[CH2:15][CH2:14][C:13]2([F:16])[CH:9]1[CH2:10][N:11]([CH3:17])[CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[F:16][C:13]12[CH2:12][N:11]([CH3:17])[CH2:10][CH:9]1[NH:8][CH2:15][CH2:14]2

Participants

4

Reactant 1

HCID 19100960HCID 19100960, compound

Product 1

HCID 19100975HCID 19100975, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

11 g (43.7 mmol, 93% pure) of 2-benzyl-5-fluoro-7-methyl-2,7-diazabicyclo[3.3.0]octane in 100 ml of ethanol are hydrogenated at 100° C. and 100 bar on 2 g of palladium-active carbon (10% Pd). The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Workup

  1. customare hydrogenated at 100° C.
  2. filtrationThe catalyst is filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-36b377cd75464fa0888ff0545f40cbe0
Source dataset
uspto-grants-1993_01
Patent number
US05177210

Reaction notes

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