Water → HCID 19100964, compound

HRID 1646037Notes

Reaction equation

HRID 1646037 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:2].O.[CH2:16]([N:19]([CH2:25][CH:26]=O)[C:20](=[O:24])[O:21][CH2:22][CH3:23])[CH:17]=[CH2:18]>C1(C)C=CC=CC=1>[CH2:7]([N:6]1[CH:5]([C:4]([O:3][CH2:1][CH3:2])=[O:14])[CH2:18][CH:17]2[CH:26]1[CH2:25][N:19]([C:20]([O:21][CH2:22][CH3:23])=[O:24])[CH2:16]2)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 962Water2×HCID 80908N-Benzylglycine ethyl esterHCID 11084330Ethyl allyl(2-oxoethyl)carbamate

Product 1

HCID 19100964HCID 19100964, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

50 g (0.25 mol) of N-benzylglycine ethyl ester in 1 l of toluene are heated under reflux in a water separator and 43 g (0.25 mol) of ethyl N-allyl-N-(2-oxoethyl)-carbamate are added dropwise during the course of two hours. The mixture is heated under reflux until water no longer separates and concentrated, and the residue is distilled.

Workup

  1. additionare added dropwise during the course of two hours
  2. temperatureThe mixture is heated
  3. concentrationconcentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-a9c8f3a8ab6b43a7a32a2608f7a39289
Source dataset
uspto-grants-1993_01
Patent number
US05177210

Reaction notes

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