Dimethylamine → HCID 19012226, compound

HRID 1646074Notes

Reaction equation

HRID 1646074 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([NH:6][C:7]([CH2:11][CH2:12][CH3:13])=[N:8]2)=[C:4]([CH3:14])[N:3]=1.[CH3:15][NH:16][CH3:17]>C(O)C>[CH3:15][N:16]([CH3:17])[C:2]1[N:10]=[C:9]2[C:5]([NH:6][C:7]([CH2:11][CH2:12][CH3:13])=[N:8]2)=[C:4]([CH3:14])[N:3]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 190122122-Chloro-6-methyl-8-propylpurine

Product 1

HCID 19012226HCID 19012226, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
110 °C

Procedure

To a solution of 2-Chloro-6-methyl-8-propylpurine (from Step 1 of Example 32) (0.1 g, 0.47 mmol) in ethanol (2 ml) was added condensed dimethylamine (1 ml) at 0° C. The mixture was then placed in a steel-bomb and heated at 110° C. for 7 hours. The reactions was cooled and the mixture was concentrated in vacuo. The residue was partitioned between CHCl3 and water, and the organic was separated and dried over MgSO4. The crude product obtained after removal of the solvent was purified by flash-chromatography on silica-gel using 5% MeOH in CHCl3 giving the titled compound as an amorphous solid (0.065 g, 64%). NMR (CDCl3): δ1.01 (t, J=8 Hz, 3H), 1.8 (q, J=8 Hz, 2H), 2.65 (s, 3H), 2.8 (t, J=8 Hz, 2H), 3.2 (s, 6H). FAB-MS: m/e 220 (M+H).

Workup

  1. temperatureThe reactions was cooled
  2. concentrationthe mixture was concentrated in vacuo
  3. customThe residue was partitioned between CHCl3 and water
  4. customthe organic was separated
  5. dry with materialdried over MgSO4

Sources & evidence

ORD record
ord-bbef1cee464c43198754c1ed1ec6ddb7
Source dataset
uspto-grants-1993_01
Patent number
US05177074

Reaction notes

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