Hydrochloric Acid → HCID 19801580, compound

Participants

Reaction Steps

2-Bromoheptanoic acid (86.0 g, 411.3 mmol) is placed in 600 ml of dimethylformamide, 49.95 g (493.6 mmol) of triethylamine are added dropwise thereto within 5 minutes at 20° C. and the pale yellow solution is stirred at room temperature for 15 minutes. Chloroacetone (57.07 g, 617 mmol) is added dropwise during 30 minutes and the yellow-brown suspension is stirred at room temperature for 90 minutes. The reaction mixture is poured on to 1 l of 1N HCl and ice and extracted in a separating funnel with 3×500 ml of ether. The organic phases are washed with 2×200 ml of water, dried over MgSO4 and concentrated on a rotary evaporator. Distillation at 86°-88° C./0.05 mbar yields 80.56 g (73.9%) of acetylmethyl 2-bromoheptanoate.

Provenance & Evidence