HCID 3042948, compound → HCID 19801710, compound

HRID 1646165Notes

Reaction equation

HRID 1646165 reaction equation
[C:1]([C:11]1[CH:20]=[CH:19][C:14]2[NH:15][C:16](=[O:18])[O:17][C:13]=2[CH:12]=1)(=[O:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C(Cl)(Cl)Cl>[O:18]=[C:16]1[NH:15][C:14]2[CH:19]=[C:20]3[C:3]([C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=4)=[CH:2][C:1](=[O:10])[C:11]3=[CH:12][C:13]=2[O:17]1

Participants

3

Reactant 1

HCID 3042948HCID 3042948, compound

Product 1

HCID 19801710HCID 19801710, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
120 °C

Procedure

1000 g of polyphosphoric acid are placed in a 1000-ml round-bottomed flask equipped with a mechanical stirrer. 119.36 g (0.45 mol) of 6-cinnamoylbenzoxazolinone, described in Application FR 73/23,281, are dissolved with stirring at a temperature of 120° C., and stirring is continued for 55 min while this temperature is maintained. The reaction mixture is hydrolyzed by vigorous stirring in 5 volumes of ice-cold water, and the product is drained, washed with water until the washes are neutral and dried. The precipitate obtained, finely powdered, is suspended in chloroform and the mixture is brought to the boil for 2 hours.

Workup

  1. customequipped with a mechanical stirrer
  2. dissolutionare dissolved
  3. stirringstirring
  4. temperatureis maintained
  5. stirringby vigorous stirring in 5 volumes of ice-cold water
  6. washwashed with water until the washes
  7. customdried
  8. customThe precipitate obtained
  9. waitthe mixture is brought to the boil for 2 hours

Sources & evidence

ORD record
ord-2d55dfa4d41545ae90348706e92e09e3
Source dataset
uspto-grants-1993_01
Patent number
US05179091

Reaction notes

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