Acetic Anhydride → HCID 67859050, compound

HRID 1646168Notes

Reaction equation

HRID 1646168 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH2:8]([O:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][C:20]=1[O:21][CH2:22][CH3:23])[C:17](=[C:24]([S:27][CH2:28][CH:29]([OH:37])[CH2:30][N:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1)[C:25]#[N:26])[NH:16][CH2:15][CH2:14]2)[CH3:9]>C1C=CC=CC=1>[CH2:8]([O:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][C:20]=1[O:21][CH2:22][CH3:23])[C:17](=[C:24]([S:27][CH2:28][CH:29]([O:37][C:1](=[O:3])[CH3:2])[CH2:30][N:31]1[CH2:32][CH2:33][O:34][CH2:35][CH2:36]1)[C:25]#[N:26])[NH:16][CH2:15][CH2:14]2)[CH3:9]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 67859005HCID 67859005, compound

Product 1

HCID 67859050HCID 67859050, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

After adding 50 ml of benzene and 20 ml of acetic acid anhydride to 3.0 g of 2-(6,7-diethoxy-1,2,3,4-tetrahydro-1-isoquinolinylidene)-2-[2-hydroxy-3-(4-morpholinyl)propyl]mercaptoacetonitrile, the reaction mixture is refluxed for 1 hour, then evaporated to dryness under reduced pressure. After addition of ether, the residue crystallizes out to give the named product in a yield of 2.47 g, m.p.: 133° C. (from isopropanol).

Workup

  1. temperaturethe reaction mixture is refluxed for 1 hour
  2. customevaporated to dryness under reduced pressure
  3. additionAfter addition of ether
  4. customthe residue crystallizes out
  5. customto give the named product in a yield of 2.47 g, m.p.: 133° C. (from isopropanol)

Sources & evidence

ORD record
ord-0f173dcd850e40359048bc4d977941a2
Source dataset
uspto-grants-1993_01
Patent number
US05179089

Reaction notes

Loading…