Glycine methyl ester hydrochloride → HCID 19801628, compound

Participants

Reaction Steps

A solution of glycine methyl ester hydrochloride (1.6 g, 12.7 mmol) and diethyl (4-bromo-2-butenyl)phosphonate (Example E) (3.14 g, 11.6 mmol) in methanol and triethylamine (5 ml) is heated at reflux for 16 hours. The solvent is removed in vacuo and the residue dissolved in water and extracted with chloroform (2×70 ml). The organic layer is dried over magnesium sulfate, filtered and evaporated. The residue is purified over silica gel (0-2.5% methanol in chloroform as eluant) to give 1.1 g of a clear oil.

Provenance & Evidence