Potassium Carbonate → HCID 19801592, compound

Participants

Reaction Steps

A suspension of potassium carbonate (0.42 g, 3 mmol) in anhydrous dimethylformamide (3 ml) is treated with glycine methyl ester hydrochloride (0.25 g, 2 mmol) and stirred under nitrogen. After 5 minutes diethyl (2-bromoethyl)thiomethylphosphonate (Example G) (0.28 g, 1.08 mmol) is added as a solution in dimethylformamide (0.5 ml). After stirring 48 hours, the dimethylformamide is removed in vacuo, and the residue is dissolved in water and extracted with chloroform (2×30 ml). The organic layer is separated, dried over sodium sulfate, filtered, evaporated, and the residue is purified by silica gel chromatography (60:1 chloroform:methanol as eluant) to give methyl N-[2-[[(diethoxyphosphinyl)methyl]thio]ethyl]glycinate.

Provenance & Evidence