3-Bromobenzyl bromide → HCID 19801606, compound

Participants

Reaction Steps

A solution of 3-bromobenzylbromide (4.3 g, 17.2 mmol) in methanol (25 ml) and triethylamine (5 ml) is treated with glycine methyl ester hydrochloride (4.3 g, 34.4 mmol) and heated to reflux for 18 hours. The solvent is removed in vacuo and the residue chromatographed over silica gel (0-2% methanol in ethyl acetate as eluant) to give 1.62 g of a yellow oil.

Provenance & Evidence