Hydrochloric Acid → 2-(3-Butynyloxy)tetrahydro-2H-pyran

Participants

Reaction Steps

A solution of 3-butyn-1-ol (74.5 g, 1.06 mol) in carbon tetrachloride (225 ml) is cooled in an ice bath, and treated with concentrated hydrochloric acid (1 ml). Dihydropyran (157 g, 1.86 mol) is then added via a dropping funnel. After stirring 16 hours the reaction mixture is treated with solid sodium bicarbonate for 30 minutes and filtered. The reaction mixture is concentrated and the residue is distilled in vacuo to give the title compound.

Provenance & Evidence