Formaldehyde → HCID 54339854, compound

HRID 1646194Notes

Reaction equation

HRID 1646194 reaction equation
[C@@H:1]12[CH2:10][CH2:9][CH2:8][NH:7][C@H:6]1[CH2:5][CH2:4][CH2:3][NH:2]2.[CH2:11]=O>[Pd]>[CH3:11][N:2]1[CH2:3][CH2:4][CH2:5][C@H:6]2[C@H:1]1[CH2:10][CH2:9][CH2:8][NH:7]2

Participants

4

Reactant 2

HCID 712Formaldehyde2×HCID 15518785HCID 15518785, compound

Product 1

HCID 54339854HCID 54339854, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of trans-2,7-diazabicyclo[4.4.0]decane (1.4 g, 10 mmoles), 37% aqueous formaldehyde solution (0.6 ml, 8 mmoles) and 0.5 g of palladium on charcoal (10%) was hydrogenated for 10 hours at 60° C. under a pressure of 3 to 4 bar. Hydrogenation under the conditions given above was continued after adding a further 0.3 ml of the 37% aqueous formaldehyde solution, the reaction mixture was then concentrated and digested with petrolether. The petrolether solution was concentrated under reduced pressure and the oily residue (1.2 g) was used for further reactions without further purification.

Workup

  1. concentrationthe reaction mixture was then concentrated
  2. concentrationThe petrolether solution was concentrated under reduced pressure
  3. customthe oily residue (1.2 g) was used for further reactions without further purification

Sources & evidence

ORD record
ord-2c4a2307ca6a4026be2ebbc02222dde5
Source dataset
uspto-grants-1993_01
Patent number
US05179090

Reaction notes

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