Sodium Hydroxide → HCID 10422267, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 11-amino-4,5-dihydro-1H-pyrazolo[3,4-a]acridine (40.0 g) in an aqueous sodium hydroxide solution (37.1 g in 561 ml of water) at 50° C. was added ethanol (1550 ml). The resulting solution was heated to 55° C. and solid hydroxylamine-o-sulfonic acid (51.6 g) was added in portions over 15 minutes. The reaction was stirred for a half hour without heat, the resulting solid was filtered, washed with water, boiled in methanol (1500 ml), filtered hot to remove inorganics, concentrated, and triturated with diethyl ether to yield 5.79 g of a product containing approximately 20% of the starting material which was inseparable by chromatography.

Provenance & Evidence