2,4,6-Trimethylpyridine → HCID 53823294, compound

Participants

Reaction Steps

Under a current of argon, a solution of 1.50 g of 4-methoxymethoxy-3-nitrocinnamyl alcohol in 15 ml of dimethyl formamide and 292 mg of anhydrous lithium chloride and 0.9 ml of 2,4,6-collidine added thereto as kept cooled with ice were stirred for 10 minutes and the produced mixture and 0.5 ml of methanesulfonyl chloride added as kept cooled with ice were stirred for four hours. The resultant reaction mixture was combined with water and extracted from ethyl acetate. The consequently separated organic layer was washed with saturated saline solution and dried with anhydrous sodium sulfate. By concentrating the residue from drying under a vacuum, 1.62 g of 4-methoxymethoxy-3-nitrocinnamyl chloride was obtained in the form of a colorless oily substance. This product was put to use in its unpurified form in the following reaction.

Provenance & Evidence