HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Fluoro-3-mercaptophenyl)-4-methoxytetrahydropyran → 4-[3-(1,3-Dimethyl-2-oxo-2,3-dihydrobenzimidazol-5-ylthio)-5-fluorophenyl]-4-methoxytetrahydropyran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Fluoro-3-mercaptophenyl)-4-methoxytetrahydropyran | HCID 18996287 | — |
| Reactant | 5-Iodo-1,3-dimethyl-2,3-dihydrobenzimidazol-2-one | HCID 22287528 | — |
| Product | 4-[3-(1,3-Dimethyl-2-oxo-2,3-dihydrobenzimidazol-5-ylthio)-5-fluorophenyl]-4-methoxytetrahydropyran | HCID 19375720 | 60% |
Reaction Steps
Using a similar procedure to that described in Example 1, 5-iodo-1,3-dimethyl-2,3-dihydrobenzimidazol-2-one was reacted with 4-(5-fluoro-3-mercaptophenyl)-4-methoxytetrahydropyran to give 4-[3-(1,3-dimethyl-2-oxo-2,3-dihydrobenzimidazol-5-ylthio)-5-fluorophenyl]-4-methoxytetrahydropyran in 60% yield, m.p. 128°-130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05179115 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-aad8e96026af4a75944c60779f3e6065 |
| Source note | uspto-grants-1993_01 |