Cyclopentylacetyl chloride → Methyl 4-[5-(2-cyclopentylacetamido)indol-3-ylmethyl]-3-methoxybenzoate

Participants

Reaction Steps

Starting from amino-ester (A), and using a similar procedure to that described in Example 4, except using cyclopentylacetyl chloride (see also Example 98), the title compound was obtained in quantitative yield as a foam; partial NMR (250 MHz, DMSO-d6): 1.2-1.8 (3 m,8 H, cyclopentyl ring); 2.24 (m,3 H, CH2CONH and --CHCH2); 3.893 (s,3 H, OMe); 3.93 (s,3 H, OMe); 3.99 (br s,2 H, CH2Ar); 9.57 (br s,1 H, NCHO); 10.79 (br d,1 H, --NH--).

Provenance & Evidence