HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1646394Generated: November 1, 2026
Sodium Carbonate → 6-Chloro-N-(3-methyl-1H-indol-1-yl)-4-pyrimidinamine
https://huagongshe.com/reaction/1646394
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | 3-Methyl-1H-indol-1-amine | HCID 12427292 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Chloro-N-(3-methyl-1H-indol-1-yl)-4-pyrimidinamine | HCID 15158246 | — |
Reaction Steps
To 125 ml of 1-methyl-2-pyrrolidinone was added 3-methyl-1H-indol-1-amine (10.0 g), and this mixture was heated to 120° C. Then 4,6-dichloropyrimidine (10.43 g), was added to the hot solution and this mixture was stirred for four hours. The reaction was cooled, poured into water, basified with Na2CO3 (aq) extracted with ethyl acetate and the organic layer washed with water and dried (sat. NaCl, anhy. MgSO4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05179204 |
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| Source dataset | uspto-grants-1993_01 |
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| ORD ID | ord-be2efe13ac344ebf9e6beb544be9fafc |
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| Source note | uspto-grants-1993_01 |
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