Acetic Anhydride → HCID 58733352, compound

HRID 16464Notes

Reaction equation

HRID 16464 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:18][C:19]2[CH:24]=[C:23]([CH:25]3[CH2:30][CH2:29][CH2:28][NH:27][CH2:26]3)[N:22]=[C:21]([NH2:31])[N:20]=2)[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[NH:15][CH:16]=[CH:17][C:10]=12.[C:32](OC(=O)C)(=[O:34])[CH3:33]>C(O)C>[C:32]([N:27]1[CH2:28][CH2:29][CH2:30][CH:25]([C:23]2[N:22]=[C:21]([NH2:31])[N:20]=[C:19]([NH:18][C:4]3[CH:5]=[CH:6][C:7]([O:8][C:9]4[CH:14]=[CH:13][N:12]=[C:11]5[NH:15][CH:16]=[CH:17][C:10]=45)=[C:2]([F:1])[CH:3]=3)[CH:24]=2)[CH2:26]1)(=[O:34])[CH3:33]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 58733356N4-[3-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-6-piperidin-3-ylpyrimidine-2,4-diamine

Product 1

HCID 58733352HCID 58733352, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

50 mg (0.119 mmol) of N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-6-piperidin-3-ylpyrimidine-2,4-diamine (from example 134) are suspended in ethanol. 0.013 ml (0.146 mmol) of acetic anhydride are added, and the mixture is stirred at room temperature for 18 hours. The mixture is then concentrated. The residue is purified by preparative HPLC.

Workup

  1. concentrationThe mixture is then concentrated
  2. customThe residue is purified by preparative HPLC

Sources & evidence

ORD record
ord-e3d68958b57043d88e239c8e9647eb30
Source dataset
uspto-grants-2010_06
Patent number
US07737153B2

Reaction notes

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