Acetic Anhydride → HCID 54199561, compound

Participants

Reaction Steps

In a 100 mL round bottomed flask fitted with a condenser closed with a calcium chloride tube, 156.3 mg (0.55 mmol) of 7 and 0.5 ml of acetic anhydride were placed. The contents of the flask were refluxed gently for 15 min. On cooling white crystals appeared. The crystals were collected on a filter, washed with ether and purified by sublimation under high vacuum (0.05 torr) at an oil bath temperature of 130° C. to yield 110 mg (75%) of the anhydride 8. White solid; mp: 178.5°-179.5° C.; IR: 3110, 3040, 2980, 1860, 1790, 1740, 1720, 1440, 1300, 1250, 1100, 910, 900 cm-1 ; 1H NMR: δ 8.38 (s, 2H, Aryl H), 3.95 (s, 6H, CH3).

Provenance & Evidence