Sodium Hydroxide → HCID 53864123, compound

Participants

Reaction Steps

A mixture of methyl 7-(4-isopropyl-4methyl-5-oxo-2-imidazolin-2-yl)-6-benzo [b]thiophene carboxylate (90% pure, 0.420 g, 1.20 mmol), aqueous sodium hydroxide (1.01 mL, 2.53 mmol) and tetrahydrofuran (15 mL) is stirred overnight at 40°-45° C., cooled to room temperature, concentrated in vacuo, and acidified to pH 1-2 with concentrated sulfuric acid. Extraction with ethyl acetate, drying (MgSO4), concentration and recrystallization from acetonitrile:hexanes (9:1) affords the title product as an off-white solid, 0.22 g, mp 200°-202° C.

Provenance & Evidence