Sodium Hydroxide → HCID 19800661, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3,4-(methylenedioxy)benzoate (6.00 g, 16.9 mmol) is added to 7.5N sulfuric (100 mL), stirred for 15 hours at reflux temperature, cooled to 0° C. and treated with 6N sodium hydroxide to pH 4. The resultant mixture is continuously extracted with ethyl acetate overnight, and the organic layer is concentrated in vacuo to afford the title product as a white solid, 3.40 g (59.1%), mp 172°-176° C.

Provenance & Evidence