Acetic Anhydride → HCID 19800655, compound

HRID 1646445Notes

Reaction equation

HRID 1646445 reaction equation
[CH:1]([C:4]1([CH3:22])[C:8](=[O:9])[NH:7][C:6]([C:10]2[C:18]3[O:19][CH2:20][O:21][C:17]=3[CH:16]=[CH:15][C:11]=2[C:12](O)=[O:13])=[N:5]1)([CH3:3])[CH3:2].C(OC(=O)C)(=O)C>>[CH:1]([C:4]1([CH3:22])[C:8](=[O:9])[N:7]2[C:12](=[O:13])[C:11]3[CH:15]=[CH:16][C:17]4[O:21][CH2:20][O:19][C:18]=4[C:10]=3[C:6]2=[N:5]1)([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 19800661HCID 19800661, compound

Product 1

HCID 19800655HCID 19800655, compound

Procedure

A mixture of 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3,4-(methylenedioxy) benzoic acid (3.40 g, 11.2 mmol) and acetic anhydride (20 mL, 0.211 mol) is stirred overnight at reflux temperature. Concentration in vacuo and recrystallized from ethyl acetate to yield the title product as a white solid, 1.50 g (46.9%), mp 237°-242° C., identified by NMR spectral analysis.

Workup

  1. temperatureat reflux temperature
  2. concentrationConcentration in vacuo
  3. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-23da10a57f8a40429e6e436ca32887dc
Source dataset
uspto-grants-1993_01
Patent number
US05180419

Reaction notes

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