HCID 19800643, compound → HCID 19800662, compound

Participants

Reaction Steps

A mixture of diethyl-4-amino-5-hydroxyphthalate (4.00 g, 15.8 mmol) and triethylorthoacetate (29.0 mL, 158 mmol) is stirred for 2 hours at reflux temperature, cooled to room temperature and diluted with hexanes. Silica gel chromatography (gradient elution:hexanes to (2:1) hexanes:ethyl acetate) followed by recrystallization from 1% ethyl acetate:-hexanes affords the title product as an off-white crystalline solid, 3.54 g (80.8%), identified by NMR, IR and mass spectral analyses.

Provenance & Evidence