反应详情

A solution of 23 g of dicyclohexylcarbodiimide in 50 ml of CH2Cl2 is added to a mixture of 16 g of 1-cyano-3-methyl-cyclohexanecarboxylic acid, 25 g of 4'-hexyl-biphenyl-4-ol, 1.2 g of 4-diethylaminopyridine and 200 ml of methylene chloride at room temperature and the mixture is stirred for 2 hours. Customary working up and separation by column chromatography (silica gel/toluene) gives 4'-hexylbiphenyl-4-yl 1-cyano-3-methylcyclohexanecarboxylic as the pure product by recrystallization, m.p. 51°, [α]D20 =+2.2°.

1. customseparation by column chromatography (silica gel/toluene)
2. customgives 4'-hexylbiphenyl-4-yl 1-cyano-3-methylcyclohexanecarboxylic as the pure product
3. customby recrystallization, m.p. 51°, [α]D20 =+2.2°