HCID 6919876, compound → Permethric acid

Participants

Reaction Conditions

Reaction Steps

Bacillus sp. DC-1 was cultivated in the same manner as in Example 38 and 0.5 g (wet weight) of cells was obtained from 100 ml of the cultured solution by centrifugation. After the harvested cells were suspended in 10 ml of 0.1M phosphate buffer solution (pH 8.0), 1.0 g of methyl (±)-cis, trans-2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropane carboxylate (cis/trans ratio=45/55) was added to the suspension and the mixture was stirred at 30° C. for 96 hours. Extraction and isolation from the resulting mixture was performed in the same manner as in Example 38, thereby 0.277 g of 2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropane carboxylic acid was obtained. All of the starting methyl 2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropane carboxylate were recovered as it was excluding that which had been converted to 2,2-dimethyl-3(2,2-dichlorovinyl)cyclopropane carboxylic acid.

Provenance & Evidence