HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylthiourea → 4-(1-(2-Fluoro-4-biphenyl)ethyl)-2-methylaminothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylthiourea | HCID 2723704 | — |
| Reactant | 1-Chloro-3-(2-fluoro-4-biphenylyl)-2-butanone | HCID 15676009 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(1-(2-Fluoro-4-biphenyl)ethyl)-2-methylaminothiazole | HCID 124238 | 72.5% |
Reaction Steps
To N-methylthiourea (5.55 g, 61.6 mmol) in water was heated with 1-chloro-3-(2-fluoro-4-biphenylyl)-2-butanone (16.50 g, 59.6 mmol) at 90° C. for 3 hr. Treatment in same manner of Example 1 to give 4-[1-(2-fluoro-4-biphenylyl)ethyl]-2-methylaminothiazole (13.5 g, 71% yield): mp 129°-129.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05180731 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-e625ebf71ef3405e946532c9ae086355 |
| Source note | uspto-grants-1993_01 |