HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → 4-(1-(2-Fluoro-4-biphenylyl)ethyl)-2-methylamino-thiazole citrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | 4-(1-(2-Fluoro-4-biphenyl)ethyl)-2-methylaminothiazole | HCID 124238 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(1-(2-Fluoro-4-biphenylyl)ethyl)-2-methylamino-thiazole citrate | HCID 19800954 | — |
Reaction Steps
To 4-(1-(2-fluoro-4-biphenylyl)ethyl)-2-methylaminothiazole (200 mg, 0.64 mmol) in methanol was added citric acid (60 mg, 0.64 mmol) in methanol and the mixture was stirred at room temperature, then evaporated under reduced pressure to a residue, which was recrystallized to afford 4-(1-(2-fluoro-4-biphenylyl)ethyl)-2-methylamino-thiazole citrate: mp 150°-151° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05180731 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-22eae9327afa4ceba347d545b90070b7 |
| Source note | uspto-grants-1993_01 |