1-Cyano-6-methoxy-2-phenylmethylcarbonyl-1,2,3,4-tetrahydronaphthalene → 2,3,3a,4,5,9b-Hexahydro-3-(3-methylphenyl)methyl-1H-benz[e]isoindole

HRID 1646583Notes

Reaction equation

HRID 1646583 reaction equation
C(C1C2C(=CC(OC)=CC=2)CCC1C(CC1C=CC=CC=1)=O)#N.[C:24]([CH:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][CH2:28][CH:27]1[C:36]([CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[C:41]([CH3:45])[CH:40]=1)=O)#[N:25]>>[CH3:45][C:41]1[CH:40]=[C:39]([CH2:38][CH:36]2[CH:27]3[CH:26]([C:35]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[CH2:29][CH2:28]3)[CH2:24][NH:25]2)[CH:44]=[CH:43][CH:42]=1

Participants

3

Reactant 2

HCID 197932031-Cyano-6-methoxy-2-phenylmethylcarbonyl-1,2,3,4-tetrahydronaphthalene2×HCID 197932601-Cyano-2-(3-methylphenyl)methylcarbonyl-1,2,3,4-tetrahydronaphthalene2×

Product 1

HCID 197932702,3,3a,4,5,9b-Hexahydro-3-(3-methylphenyl)methyl-1H-benz[e]isoindole

Procedure

Following the procedures described in Step 2 of Example 6, replacing 1-cyano-6-methoxy-2-phenylmethylcarbonyl-1,2,3,4-tetrahydronaphthalene (the product of Step 1 of Example 6) with the product of Step 1 above, 1-cyano-2-(3-methylphenyl)methylcarbonyl-1,2,3,4-tetrahydronaphthalene, the title compound was prepared; MS DCI-NH3M/Z: 278 (M+H)+.

Sources & evidence

ORD record
ord-382ffe12846e45718f8b5a9ec8c26368
Source dataset
uspto-grants-1993_01
Patent number
US05180733

Reaction notes

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