HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[2-Amino-6-chloro-4-pyrimidinyl]-N-[3-fluoro-4-(1H-indazol-5-yloxy)phenyl]amine → N4-[3-Fluoro-4-(1H-indazol-5-yloxy)phenyl]pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[2-Amino-6-chloro-4-pyrimidinyl]-N-[3-fluoro-4-(1H-indazol-5-yloxy)phenyl]amine | HCID 17979350 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N4-[3-Fluoro-4-(1H-indazol-5-yloxy)phenyl]pyrimidine-2,4-diamine | HCID 58733398 | — |
Reaction Steps
50 mg (0.135 mmol) of 6-chloro-N4-[3-fluoro-4-(1H-indazol-5-yloxy)phenyl]pyrimidine-2,4-diamine (from example 8) are dissolved in ethanol. 50 mg of 10% palladium-on-carbon are added, and the suspension is stirred overnight under an atmosphere of hydrogen. The palladium catalyst is filtered off with suction and the filtrate is concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737153B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-f282461f438f4e4dba764611784a4da3 |
| Source note | uspto-grants-2010_06 |