反应详情

2 g of 6-bromo-indanone, 10 ml of dimethylformamide and 3 g of copper cyanide are taken to reflux for 20 hours. At 20° C. the reaction mixture is poured into 40 ml of water and 30 ml of methylene chloride, agitated for 15 minutes and filtered on celite. The filtrate is decanted and re-extracted with methylene chloride. The organic phase is washed with water, dried, brought to dryness under reduced pressure and the residue is chromatographed on silica in a hexane-ethyl acetate mixture as eluant (7-3). 1.03 g of expected product is obtained, M.p.=109° C.

1. temperatureto reflux for 20 hours
2. filtrationfiltered on celite
3. customThe filtrate is decanted
4. extractionre-extracted with methylene chloride
5. washThe organic phase is washed with water
6. customdried
7. customthe residue is chromatographed on silica in a hexane-ethyl acetate mixture as eluant (7-3)