4-Bromobenzyl bromide → HCID 19801019, compound

Participants

Reaction Steps

In chloroform (0.5 ml) were dissolved 2-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-3-methoxy-1-methylthiomethyl-1,4-cyclohexanediol (200 mg) and 4-bromobenzyl bromide (756 mg). To the solution was added silver bromide (11.4 mg), and the mixture was stirred for 28 hours. Insolubles were filtered off, and the solvent was distilled off. The residue was pulverized by the addition of ether. The resulting powder was dissolved in methanol (2 ml). Insolubles were filtered off, then the solvent was distilled off under reduced pressure. The residue was pulverized by the addition of ether to give 1-(4-bromobenzyl)methylsulfoniomethyl-2-(1,2-epoxy- 1,5-dimethyl-4-hexenyl)-3-methoxy-1,4cyclohexanediol bromide (176 mg: yield 50%) as colorless powder.

Provenance & Evidence