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1,3-Propanedithiol → 2-Fluoroadenine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Propanedithiol | HCID 8013 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 6-azido-2-fluoro-7H-purine | HCID 19801267 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-Fluoroadenine | HCID 12790 | 92.8% |
反応手順
Triethylamine (0.40 mL) was added via syringe to a solution of 6-azido-2-fluoropurine (0.256 g) and 1,3-propanedithiol (0.29 mL) in methanol (13.5 mL). After 15 minutes the reaction was complete as judged by TLC and a white precipitate had formed. The precipitate was collected by filtration and washed with two 10 mL portions of methanol and then dried to obtain 0.203 g of 2-fluoroadenine, mp>300° C. This material was identical to an authentic sample by TLC, NMR and IR.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05180824 |
| 出典データセット | uspto-grants-1993_01 |
| ORD ID | ord-d089e88f144d47ecba88e636713cf25d |
| 出典メモ | uspto-grants-1993_01 |