Acetic Anhydride → 1-Acetyl-1,2-dimethyl-3-nitroisothiourea

Participants

Reaction Steps

To a mixture of 1,2-dimethyl-3-nitroisothiourea (2.93 g), potassium carbonate (4.07 g), and acetonitrile (60 ml) was added acetic anhydride (2.53 g) at room temperature and the mixture was stirred for 3 hour at this temperature. Insoluble materials were removed by filtration and the filtrate was concentrated. Chloroform (100 ml) was added to the residue and the mixture was washed with water twice. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated to give 3.48 g of 1-acetyl-1,2-dimethyl-3-nitroisothiourea.

Provenance & Evidence