Ridogrel → HCID 23712398, compound

HRID 1646685Notes

Reaction equation

HRID 1646685 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](/[C:7](=[N:18]/[O:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])/[C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[CH:2]=1.C[O-].[Na+:29]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](/[C:7](=[N:18]/[O:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]([O-:26])=[O:25])/[C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[CH:2]=1.[Na+:29]

Participants

4

Reactant 2

HCID 5362391RidogrelHCID 10942334Sodium Methoxide

Product 1

HCID 23712398HCID 23712398, compoundYield 56.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a stirred solution of 1 part of (E)-5-[[[(3-pyridinyl)[3-(trifluoromethyl)phenyl]methylen]amino]oxy]pentanoic acid in 40 parts of methanol were added 2.94 parts of a sodium methoxide solution in methanol. The reaction mixture was evaporated. The precipitated product was filtered off and dried at 60° C., yielding 0.6 parts (56.5%) of sodium (E)-5-[[[(3-pyridinyl)[3-(trifluoromethyl)phenyl]methylen]amino]oxy]pentanoate; mp. 215.9° C. (compound 121).

Workup

  1. customThe reaction mixture was evaporated
  2. filtrationThe precipitated product was filtered off
  3. customdried at 60° C.

Sources & evidence

ORD record
ord-45cbb83ddf74427a8007274dca356495
Source dataset
uspto-grants-1993_01
Patent number
US05180832

Reaction notes

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