Thionyl Chloride → HCID 19801333, compound

To a solution of 6.4 g (42 mmol) of 2-ethylaminobenzyl alcohol (prepared by reducing methyl 2-acetamidobenzoate with lithium aluminum hydride) in 90 ml of dry benzene was dropwise added under chilling with ice 4.6 ml (62 mmol) of thionyl chloride in 90 ml of dry benzene for 20 min. The mixture was stirred for 1 hr. at room temperature and subsequently 20 min. at 50° C. The solvent was distilled off under reduced pressure at a temperature below 50° C. to leave 7.7 g of 2-ethylaminobenzyl chloride hydrochloride as a brown oil. The obtained hydrochloride (7.7 g, 35 mmol) was portionwise added to a solution of 3.7 g (37 mmol) of 2-mercaptoimidazole in 60 ml of ethanol. The mixture was then stirred for 1 hr. Ethanol was distilled off under reduced pressure at a temperature below 40° C. The residue was shaken with saturated aqueous sodium hydrogencarbonate and chloroform. The chloroform portion was taken out and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue was crystallized by addition of ether to give 4.78 g of the desired compound as a pale yellow crystalline powder.

1. customat room temperature
2. customsubsequently 20 min.
3. customat 50° C
4. distillationThe solvent was distilled off under reduced pressure at a temperature below 50° C.

ORD record

ord-2c2a878f339f4cccb2aa9d428124358d

Source dataset

uspto-grants-1993_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05180836