HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 19787126, compound → HCID 13050347, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 19787126 | HCID 19787126 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 13050347 | HCID 13050347 | 84.3% |
Reaction Steps
The mixture of 3-isopropyl-2-hydroxymethylindole (29 g) and manganese dioxide (66.7 g) in ethyl acetate (435 ml) was reflux for 2 hours. After filtration of the insoluble materials, the filtrate was evaporated in vacuo. The residue was purified by silica gel column chromatography (10% ethyl acetate-toluene) to give 3-isopropyl-2-indolecarbaldehyde (24.2 g) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05180728 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-28ea3fb961e64153930804765376e217 |
| Source note | uspto-grants-1993_01 |