Hydrochloric Acid → HCID 54364246, compound

Participants

Reaction Steps

To a solution of 3-ethyl-2-indolecarbaldehyde (4.0 g) and nitromethane (4.93 g) in methanol (80 ml) was added dropwise 50% aqueous sodium hydroxide solution at 0~-5° C. for an hour. After being stirred at the same temperature for an hour and at room temperature an hour. The mixture was poured into a mixture of chilled water and 12N hydrochloric acid (4:1, 500 ml). The precipitates were collected, washed with water and dried to give 3-ethyl-2-(2-nitrovinyl)indole.

Provenance & Evidence