HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(hydroxymethyl)phthalimide → Succinimide, N-((dimethylamino)methyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(hydroxymethyl)phthalimide | HCID 8354 | — |
| Reactant | N-(Hydroxymethyl)nicotinamide | HCID 77116 | — |
| Reactant | N-(hydroxymethyl)benzamide | HCID 80493 | — |
| Reactant | N-(Hydroxymethyl)succinimide | HCID 95286 | — |
| Reactant | 1-(Hydroxymethyl)imidazolidine-2,4-dione | HCID 13644396 | — |
| Product | Succinimide, N-((dimethylamino)methyl)- | HCID 217169 | — |
Reaction Steps
Materials: N-(hydroxymetyl)-benzamide (Hellman, H, Angew. Chem. 69 (1957), 470), N-(hydroxymethyl)-nicotinamide (Chechelska, B. & Urbanski, T., Roczniki Chem. 27, 396-409), N-(hydroxymethyl)-phthalimide (Buch, S. R., J. Am. Chem. Soc. 69 (1947) 254- ), N-(hydroxymethyl)-hydantoin (Konishiroku Photo Industr. Co. Ltd. Japan 6882 ('58) Aug. 20, Chemical Abstracts 54, 135h), N-hydroxymethyl succinimide (Vail, S. L. & Pierce, A. G., J. Org. Chem. 37 (1972) 393-), and the Mannich bases N-dimethylaminomethyl nicotinamide (Singh, G. et al., Indian J. Pharm. 30 (1968) 231-3) and N-dimethylaminomethyl succinimide (Boehme, H. et al., Ann. Chem. 664 (1963) 130-40) were produced in a known manner.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05182081 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-d3bf2fab1aec416a9960808bff338b4c |
| Source note | uspto-grants-1993_01 |