HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromooctane → 4,4'-Dioctyloxy-3,3'-difluorobiphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromooctane | HCID 8140 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Boronic acid, [3-fluoro-4-(octyloxy)phenyl]- | HCID 10611926 | — |
| Reactant | 1-(Benzyloxy)-4-bromo-2-fluorobenzene | HCID 18757491 | — |
| Reactant | 4'-Octyloxy-3,3'-difluorobiphenol | HCID 19799917 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 4,4'-Dioctyloxy-3,3'-difluorobiphenyl | HCID 19799865 | — |
Reaction Steps
A mixture of 4'-octyloxy-3,3'-difluorobiphenol (0.1 mol, obtained by coupling 3-fluoro-4-octyloxyphenyl boronic acid with 4-benzyloxy-3-fluoro-brombenzene followed by hydrogenolytic cleavage of the benzylic ether), 1-bromooctane (0.12 mol), potassium carbonate (30 g) and butanone (125 ml) is heated under reflux and stirred for 20 hrs. After cooling the reaction mixture is filtered and the filtrate evaporated off, distillation under reduced pressure affords the required product, m.p. 84°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05182047 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-96a5762e0ede4c1c80364ac093936b53 |
| Source note | uspto-grants-1993_01 |