Ethanolamine → HCID 14209234, compound

HRID 1646852Notes

Reaction equation

HRID 1646852 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH2:13]([CH2:15][NH2:16])[OH:14]>O>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:16][CH2:15][CH2:13][OH:14])=[CH:9][CH:8]=[CH:7][CH:6]=2

Participants

4

Reactant 2

HCID 700EthanolamineHCID 6183063-Bromo-4-chloroquinoline

Product 1

HCID 14209234HCID 14209234, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of 9.1 g of 3-bromo-4-chloro-quinoline and 2.0 g of ethanolamine was heated at 150° C. for 30 minutes. The reaction mixture was cooled, 60 ml of water was added and the precipitate was collected by filtration and recrystallized from isopropanol. The yield was 9.5 g, mp 163°-165° C.

Workup

  1. temperatureThe reaction mixture was cooled
  2. filtrationthe precipitate was collected by filtration
  3. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-2409ecd8fd9f41c08c040ff187eb3d5f
Source dataset
uspto-grants-1993_01
Patent number
US05182275

Reaction notes

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