Water → HCID 14209239, compound

HRID 1646857Notes

Reaction equation

HRID 1646857 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][CH:8]=[CH:7][CH:6]=2.[OH2:13]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:4][CH2:3][CH:2]([OH:13])[CH3:11])=[CH:9][CH:8]=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 962WaterHCID 6183063-Bromo-4-chloroquinoline

Product 1

HCID 14209239HCID 14209239, compound

Conditions

Temperature
150 °C

Procedure

A mixture of 3 g of 3-bromo-4-chloro-quinoline and 10 g of aminopropanol-2 was heated to 150° C. for 20 minutes. The mixture was cooled and poured into 120 ml of water and the product was extracted with 100 ml of ether. The ether layer was dried over sodium sulfate, the solvent removed by evaporation and the residue recrystallized from ether/hexane. The yield was 2.6 g, mp 82°-83° C.

Workup

  1. temperatureThe mixture was cooled
  2. extractionthe product was extracted with 100 ml of ether
  3. dry with materialThe ether layer was dried over sodium sulfate
  4. customthe solvent removed by evaporation
  5. customthe residue recrystallized from ether/hexane

Sources & evidence

ORD record
ord-660266b9542845be9f2fdabbdbeeeb72
Source dataset
uspto-grants-1993_01
Patent number
US05182275

Reaction notes

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