反应详情

Bromine (33.7 g) was added dropwise to a solution of 49 g of N-(2,3-dihydroxypropyl)-2-methyl-4-quinolinamine in 600 ml of acetic acid. After two hours of stirring, the resultant oil was separated by decantation, dissolved in 500 ml of water and the mixture made alkaline (pH=10) with potassium carbonate. The resultant free base solid was filtered and recrystallized from ethanol. The yield was 33 g, mp 140°-141° C.

1. customthe resultant oil was separated by decantation
2. dissolutiondissolved in 500 ml of water
3. filtrationThe resultant free base solid was filtered
4. customrecrystallized from ethanol