8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide → HCID 86746507, compound

HRID 1646896Notes

Reaction equation

HRID 1646896 reaction equation
CO[C:3](=[O:16])[CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:9])=[O:8].[Cl:17][C:18]1[CH:36]=[CH:35][C:21]2[O:22][C:23]3[CH:34]=[CH:33][CH:32]=[CH:31][C:24]=3[CH2:25][N:26]([C:27]([NH:29][NH2:30])=[O:28])[C:20]=2[CH:19]=1>>[C:10]1([S:7]([NH:6][CH2:5][CH2:4][C:3]([NH:30][NH:29][C:27]([N:26]2[CH2:25][C:24]3[CH:31]=[CH:32][CH:33]=[CH:34][C:23]=3[O:22][C:21]3[CH:35]=[CH:36][C:18]([Cl:17])=[CH:19][C:20]2=3)=[O:28])=[O:16])(=[O:8])=[O:9])[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 135604618-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazideHCID 19800028HCID 19800028, compound

Product 1

HCID 86746507HCID 86746507, compound

Procedure

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[3-[(phenylsulfonyl)amino]-1-oxopropyl]hydrazide (24) was prepared from N-(phenylsulfonyl)-β-alanine, methyl ester (23), prepared as described above in Example 23, and 8-chlorodibenz[b,f][1,4]-oxazepine-10(11H)-carboxylic acid, hydrazide (1), prepared as described above in Example 1, on a two mmol scale in the manner described in Example 18 above to yield 0.44 g (44%) of product.

Workup

  1. customprepared
  2. customprepared

Sources & evidence

ORD record
ord-9f96dabbd7ec4f3c99a4de7d0458993a
Source dataset
uspto-grants-1993_01
Patent number
US05182272

Reaction notes

Loading…