2-Thiophenesulfonyl chloride → 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)carboxylic acid

HRID 1646899Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1646899
Cl.NCCC(NN[C:9]([N:11]1[CH2:17][C:16]2[CH:18]=[CH:19][CH:20]=[CH:21][C:15]=2[O:14][C:13]2[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:12]1=2)=[O:10])=O.S1C=CC=C1S(Cl)(=O)=[O:33]>>[Cl:26][C:24]1[CH:23]=[CH:22][C:13]2[O:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[CH2:17][N:11]([C:9]([OH:10])=[O:33])[C:12]=2[CH:25]=1

Komponenten

3

Edukt 2

HCID 855182-Thiophenesulfonyl chlorideHCID 1317177198-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(3-amino-1-oxopropyl)hydrazide, monohydrochloride

Produkt 1

HCID 219834678-chlorodibenz[b,f][1,4]oxazepine-10(11H)carboxylic acid

Versuchsvorschrift

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-[(2-thienylsulfonyl)amino]propyl hydrazide (30) was prepared from 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)carboxylic acid, 2-(3-amino-1-oxopropyl)hydrazide, monohydrochloride (9), prepared as described above in Example 9, and 2-thiophenesulfonyl chloride in the same manner as described in Example 10 on a 1.9 mmol scale to yield 0.48 g (50%) of product. Analysis calculated for C21H19N4O5ClS2 (M.W. 506.99): C, 49.26; H, 4.36; N, 12.77; Cl, 6.99; S, 12.65. Found: C, 49.05; H, 4.40: N, 12.66; Cl, 7.13; S, 12.88.

Aufarbeitung

  1. customprepared

Quellen und Nachweise

ORD-Eintrag
ord-39d6335a4c324eefb973c86d7c104bc5
Quelldatensatz
uspto-grants-1993_01
Patentnummer
US05182272

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