HCID 19021618, compound → 1-(2-Amino-2-phenylethyl)-4-[10-(2tetrahydropyranyloxy)decyl]piperazine
Reaction equation
C(OC(N(C1C=CC=CC=1)CC(O)=O)=O)(C)(C)C.O1CCCCC1OCCCCCCCCCCN1CCNCC1.[NH2:42][CH:43]([C:69]1[CH:74]=[CH:73][CH:72]=[CH:71][CH:70]=1)[C:44]([N:46]1[CH2:51][CH2:50][N:49]([CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][O:62][CH:63]2[CH2:68][CH2:67][CH2:66][CH2:65][O:64]2)[CH2:48][CH2:47]1)=O>>[NH2:42][CH:43]([C:69]1[CH:74]=[CH:73][CH:72]=[CH:71][CH:70]=1)[CH2:44][N:46]1[CH2:47][CH2:48][N:49]([CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][O:62][CH:63]2[CH2:68][CH2:67][CH2:66][CH2:65][O:64]2)[CH2:50][CH2:51]1Participants
Procedure
A 583 mg (1.40 mmoles) quantity of 1-benzyl-4-[10-(2-tetrahydropyranyloxy)decyl]piperazine was dissolved in 20 ml of ethanol, and 200 mg of 10% palladium-carbon was added thereto and the mixture was shaken at 3 atm. for 8 hours under a hydrogen atmosphere. The catalyst was filtered off and the filtrate was evaporated to dryness, giving 375 mg (yield: 82%) of N-[10-(2-tetrahydropyranyloxy)decyl]piperazine. Then, using N-t-butoxycarbonylphenylglycine and N-[10-(2-tetrahydropyranyloxy)decyl]piperazine, 1-(2-amino-2-phenylacetyl)-4-[10-(2-tetrahydropyranyloxy)decyl]piperazine was prepared in the same manner as in Reference Example 1. The obtained product was treated by the same procedure as in Reference Example 3, giving 384 mg (yield: 75%) of 1-(2-amino-2-phenylethyl) -4-[10-(2tetrahydropyranyloxy)decyl]piperazine.
Workup
- customwas prepared in the same manner as in Reference Example 1
- additionThe obtained product was treated by the same procedure as in Reference Example 3
Sources & evidence
- ORD record
- ord-108b09fb3d5a49a8886122c6b260f8b5
- Source dataset
- uspto-grants-1993_01
- Patent number
- US05182284
Reaction notes
Loading…