HCID 85623257, compound → HCID 85623259, compound

Participants

Reaction Steps

A mixture of 0.29 g of the free base of (14) (0.001 mol) and 0.15 g PtO2 in 50 ml of ethanol was hydrogenated overnight at 60 psi of H2. The catalyst was filtered off and the solvent evaporated to give 0.22 g of a clear liquid. The oxalate salt (15), 0.15 g, crystallized from ethyl acetate as a floculant colorless solid, mp 137°-138° C. NMR ppm (CDCl3) 0.9 (3H, t), 1.3-1.55 (6H, m), 1.6-1.9 (4H, m), 2.1 (2H, m), 2.45 (1H, m), 3.25 (1H, m), 3.35-3.65 (4H, m), 3.72 (1H, t), 4.25 (1H, q), 4.35 (2H, t), 8.05 (1H, d), 8.1 (1H, d). Anal. C17H27N3O-C2H2O4 requires C: 60.14; H: 7.70; N: 11.07%. Found C: 60.29; H: 7.91; N: 10.85%.

Provenance & Evidence