Ammonia → 135205-37-7

HRID 1646960Notes

Reaction equation

HRID 1646960 reaction equation
[C:1]([O:5][CH:6]1[O:9][CH:7]1[CH3:8])([CH3:4])([CH3:3])[CH3:2].[NH3:10]>>[NH2:10][CH2:8][CH:7]([OH:9])[CH2:6][O:5][C:1]([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 19012495HCID 19012495, compound

Product 1

HCID 19012483135205-37-7

Procedure

100 g of 1,2-epoxypropyl tert.-butyl ether are added dropwise to 500 ml of conc. aqueous ammonia under ice-cooling and the mixture is stirred at room temperature for 20 hours. The reaction mixture is evaporated under reduced pressure to remove the aqueous ammonia. Chloroform is added to the residue. The mixture is dried with potassium carbonate. Insoluble materials are filtered off and the filtrate is evaporated to remove the solvent. The residue is distilled under reduced pressure. 49.3 g of 1-amino-3-tert.-butoxy-2-propanol are obtained.

Workup

  1. temperaturecooling
  2. customThe reaction mixture is evaporated under reduced pressure
  3. customto remove the aqueous ammonia
  4. additionChloroform is added to the residue
  5. dry with materialThe mixture is dried with potassium carbonate
  6. filtrationInsoluble materials are filtered off
  7. customthe filtrate is evaporated
  8. customto remove the solvent
  9. distillationThe residue is distilled under reduced pressure

Sources & evidence

ORD record
ord-55116f577778492f96b8df902bd9e49b
Source dataset
uspto-grants-1993_01
Patent number
US05182296

Reaction notes

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