N-Formylmorpholine → HCID 14995662, compound

Participants

Reaction Conditions

Reaction Steps

83 ml of butyllithium were added at -70° C. to a mixture of 36.4 g of the product of Step B and 100 ml of tetrahydrofuran and the mixture was stirred for one hour at -60° C., 24.2 ml of N-formyl morpholine in 50 ml of tetrahydrofuran were added and the reaction mixture was stirred for 16 hours at -60° C. Ammonium chloride was added and the two phases were decanted. Extraction was carried out with ethyl acetate, followed by drying and concentrating to obtain 35.12 g of product which was purified by chromatography on silica, eluting with a hexane - ethyl acetate mixture (9-1) to obtain 13.8 g of the desired product.

Provenance & Evidence