Methanol → HCID 67876006, compound

HRID 1646968Notes

Reaction equation

HRID 1646968 reaction equation
[C:1]1([C:7]2([CH2:16][C:17]#N)[CH2:15][CH:14]=[C:10]3[CH:11]=[CH:12][CH:13]=[C:9]3[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO.[OH-:21].[Na+].[OH2:23]>>[C:1]1([C:7]2([CH2:16][C:17]([OH:23])=[O:21])[CH2:15][CH:14]=[C:10]3[CH:11]=[CH:12][CH:13]=[C:9]3[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 4

HCID 887Methanol2×HCID 962Water2×HCID 14798Sodium HydroxideHCID 67875982HCID 67875982, compound

Product 1

HCID 67876006HCID 67876006, compound

Procedure

A suspension of 24.68 g of the product of Step A, 200 ml of methanol, 100 ml of water and 160 ml of a ION sodium hydroxide solution was refluxed for 16 hours and the methanol was eliminated. The product was taken up in water and washed with methylene chloride. Acidification was carried out with 150 ml of a 12N hydrochloric acid solution. The product was separated out, made into a paste in water and dried to obtain 22 g of the desired product melting at 139.1° C.

Workup

  1. temperaturewas refluxed for 16 hours
  2. washwashed with methylene chloride
  3. customThe product was separated out
  4. customdried

Sources & evidence

ORD record
ord-632893d13c7640608037fbdddc78be67
Source dataset
uspto-grants-1993_01
Patent number
US05182295

Reaction notes

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